Saturday, October 10, 2009
Give Me One Good Reason
Friday, September 4, 2009
Family Tree
Monday, August 31, 2009
Wednesday, August 12, 2009
Another reason why I hate Republicans
Wednesday, August 5, 2009
Quote of the Day
A Primer on Soy Isoflavones
Monday, August 3, 2009
How to be supportive to loved ones facing infertility
Sunday, July 19, 2009
Why the manufacturers of Reglan (metoclopramide) need to pay up
You might have seen the notices in the papers or the ads on TV. It's a familiar sight. Personal injury law firms circling like vultures around pharmaceutical companies because some people might have adverse effects from a popular drug. It seems like another form of ambulance chasing, doesn't it?
I used to think so.
Reglan (metoclopramide) is a drug commonly used as an antiemetic, in patients with delayed gastric emptying, and far too often an all purpose panacea for all things gastrointestional. Most people usually only need a few doses. However, those with chronic GI problems, the drug has been prescribed for months, even years.
Therein lies the problem.
The manufacturers have failed to inform healthcare professionals and patients that the drug shouldn't be used for longer than 12 weeks. Well, actually, that was true until February of this year, when the FDA required that the drug carry a black box warning. This warning stated the risk of "tardive dyskinesia" in long term use or high doses.
Black box warnings seem like something we see in some newer drugs where not enough time has passed to see any long term implications of using the drug. What makes this particular black box warning especially frustrating is that the manufacturers knew of the risk of tardive dyskinesia with long term use OVER 20 YEARS AGO.
The first suit filed over Reglan and its adverse effects went to court in 1989. And it has hardly been a rare occurence. So why has it taken over 20 years for the manufacturers to inform the medical community and patients of this risk? The drug's patent was protected until 1982. This means the original manufacturer no longer had a proprietary interest in it because other pharmaceutical companies could make a cheaper, generic version of the drug.
Whatever the reason, these 20 years of knowing, yet not informing the public of the drug's potential risks has been devastating to some patients.
Tardive dyskinesia is a disorder in which the patient experiences repetitive, involuntary movements like grimacing, tongue protrusion, lip smacking, puckering and pursing of the lips, and rapid eye blinking. Rapid movements of the extremities may also occur. Impaired movements of the fingers may also appear.
TD is usually seen as a consequence of long term use of antipsychotic drugs and neuroleptic drugs such as antiseizure medications. And now we know, Reglan. The difference is that many doctors who are presented with a patient exhibiting TD can usually figure out the culprit right away. TD caused by Reglan is often being diagnosed as a Parkison type disorder and consequently, is not treated properly. This results in continued use of the Reglan which results in symptoms that worsen with time which results in continued misdiagnosis and treament, making it a vicious cycle.
If the Reglan is discontinued soon after symptoms appear, recovery from TD is good. Unfortunately, if it is not, the TD can be permanent and often worsens even after the drug is stopped.
This is exactly what has happened to my mother. She had been on Reglan since 2002 after surgery for stomach cancer. Because of the lack of warnings, when she displayed TD symptoms, Reglan as the cause was missed. She continued the drug for over a year after her symptoms started. By the time these black box warnings were brought to the forefront, it was too late for her. She will likely never recover from TD.
Here is a video showing some patients with TD. As you can see, TD isn't just a disorder of annoying tics, it's something that can be and is debilitating for some. My mother and countless others like her are victims of neglect by the manufacturers of the drug. And because of this, they should pay up.
Danny's Top 10 Dream Cars
Saturday, July 18, 2009
Searching for the other half of me
Danny (my husband) and I have talked about my searching. At first he didn't give it much thought other than maybe I should consider all the consequences of my search. Like the fact that his family might not know about me and how that would affect his relationships with his wife, children, or other family members. I've considered this too and in the past, it had kept searching in earnest at bay for me.
Now that I'm older, this is what I think about it.
Why should I continually deny myself of what is rightfully mine to know just so I won't expose someone's "dirty little secret"? Don't I have the right to know my father and my brothers and sisters and extended family? I think I do. And so do my future children.
For too long I've lived with this missing piece in my heart. Over the years I thought that finding my soulmate would fill that ache. As wonderful as Danny is, it hasn't. I used to think children would do it. Granted, I don't have children yet, but I somehow just know that they won't either.
The reason that no one else will fill that hole for me is because he is half of what makes me whole. My mother alone cannot bridge that gap.
So in my quest to find that missing piece, I'm throwing myself in headfirst into this search. I'm not sure what expectations to have. I'm excited about the prospect and at the same time, terrified beyond belief.
Wish me luck on my journey.